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Jay Leno hosts his final ‘Tonight’ show

Jay Leno hosts his final ‘Tonight’ show

FINAL SHOW: Actor/comedian Billy Crystal, left, serenades "Tonight Show" host Jay Leno with "Dear Mr. Leno" during the inauguration of "The Tonight Show With Jay Leno" at NBC Studios in Burbank, May 26, 1992. The song Crystal sang was a parody of Bette Midler's ode to Carson on his penultimate show last week. Crystal was Leno's first guest. Leno will end the show much like he began it in 1992, with Crystal as his guest. Photo: Associated Press/Craig Fujii

PASADENA, Calif. (AP) — Jay Leno’s last night as the host of the “Tonight” show will feature Billy Crystal, who was Leno’s first guest in May 1992.

Leno’s final show airs tonight.

Leno’s top target during his two-decade tenure as NBC’s “Tonight” show host was Bill Clinton.

The comic has cracked a total of 4,607 jokes at the expense of the former president.

WATCH: Jay Leno’s highlight reel

The Washington-based Center for Media and Public Affairs counted and catalogued nearly 44,000 jokes Leno made about politics and public affairs during his time at “Tonight,” which ends Thursday.

The center’s director, Robert Lichter, said Tuesday that Leno loves politics and scandal — and Clinton generously provided material on both accounts.

Second on Leno’s list — with 3,239 jokes at his expense — was former President George W. Bush.

Jimmy Fallon takes over the Tonight show Feb. 17, with fellow “SNL” alum Seth Myers taking over Fallon’s former show, which airs after “Tonight.”

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Amanda Knox murder conviction overturned

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Italy's highest court has overturned the murder conviction against Amanda Knox, bringing to a definitive end the high-profile case.

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Time for Iran to make tough decisions in nuclear talks

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This week’s top sports shots

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A look at some of the biggest plays and best photos in sports this week.